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Lilian.Calderon

Profile

Name: Lilian Calderón-Garcidueñas

Title: Full Professor

Email: lilian.calderon-garciduenas@umontana.edu

Phone: 406-243-4785

Office: SB 287

Lab Phone: 406-243-4793

Lab: SB 288

 

Background

   Lilian Calderón-Garcidueñas grew-up is a small Gulf of Mexico town, the oldest daughter of two young physicians, she was raised in a nurturing environment where the daily contact with patients was the rule and over dinner conversations were delightful ways to start her in medical and literature subjects, two main interest of her parents. She knew she wanted to be a physician by the time she finished middle school and she started medical school at age 15.  The following year, she was the TA’s to the Chair of Embryology at the National University Medical School in Mexico City and started her life-long passion for teaching. Her first day as a TA’s in medical school surrounded by ~40 much older first year students,  she was told she was in the wrong place, the middle school was 3 blocks away. Her love for exploring disease causes started in medical school and she decided to pursue her studies in the USA and Canada. Her pathology and neuropathology training at the University of Toronto were followed by her fellowship at Harvard University and her first position as an Assistant professor at Northwestern University in Chicago. She earned an American Board in Anatomical Pathology and Neuropathology in 1981. Literature was always in her mind, so she went back to school and earned a BS in English Literature and a MA in Comparative Literature in 1997. Her interest for clinical environmental research took her back to Chapel Hill, North Carolina where she earned a PhD in Toxicology in 2001, followed by three years as a postdoctoral fellow in Environmental Pathology.  She loves her work, her teaching is key to her way to transmit her contagious enthusiasm for medicine, science and her research work and in her free time she paints, cooks and tenders her vegetable garden and cooks some more. Her husband is a UM 2011 graduate with a PhD in History and with two children also UM alumni, her house is surrounded by grizzly memorabilia.

 

Research Statement

Researchers share their passion for science (please go to the link KPAX TV video)

http://www.kpax.com/news/um-study-looks-at-how-air-pollution-and-effects-young-brains/

 

Area of Research

My research is deeply interdisciplinary as it covers pathology, neuropathology, environmental toxicology, pediatrics, neurology, psychiatry, atmospheric chemistry, cognitive neuropsychology, developmental science, sociology of education, and educational psychology. In spite of the evident eclecticism, the scientific questions I am after pertain to fundamental issues in how the environment impacts people’s health. More specifically, I have been working on the effects of air pollutants such as particulate matter (PM) upon the brain in development.

We live in complex environments surrounded by mostly hidden chemical, biological and physical hazards. Our central mission is to work with a community of multidisciplinary researchers interested in the mechanisms of environmentally-induced diseases, in solving the problems facing our vulnerable populations, and in implementing an integrative approach to human environmental disease.

Research links air pollution mostly to respiratory and cardiovascular disease. The effects of air pollution on the central nervous system (CNS) are not broadly recognized. Urban outdoor pollution is a global public health problem particularly severe in megacities and in underdeveloped countries, but large and small cities in the United States, Canada and Mexico and across the world are not spared. Fine and ultrafine particulate matter (UFPM) defined by aerodynamic diameter (<2.5-μm fine particles, PM2.5, and <100-nm UFPM) pose a special interest for the brain effects given the capability of very small particles to reach the brain.

In adults, ambient pollution is associated to stroke, depression and suicide, whereas the emerging picture in children show significant systemic inflammation, immunodysregulation at systemic, intratechal and brain levels, neuroinflammation and brain oxidative stress, along with the main hallmarks of Alzheimer and Parkinson's diseases: hyperphosphorilated tau, amyloid plaques and misfolded α-synuclein.

The applied spin of my research has been on the cognitive and structural detrimental brain impact of air pollutants upon healthy children. How specific air pollutants reach the brain and start a cascade of events producing significant inflammation and changes in proteins that are key players in Alzheimer and Parkinson’s diseases? How a seemingly healthy child can lost >10 point in their IQ for living in a polluted city?

Pediatric air pollution research requires extensive multidisciplinary collaborations to accomplish a critical goal: to protect exposed children through multidimensional interventions having both broad impact and reach. Protecting children and teens from neural effects of air pollution should be of pressing importance for public health and we need your support.

My research contributions can be subdivided in the following five areas (for each area, a representative publication is indicated):

 

Publications

1.Making the link between air pollution exposures and the development of Alzheimer and Parkinson’s diseases in childhood and young adults.

Children residents in large cities exhibit an early brain imbalance in genes involved in oxidative stress, inflammation, and innate and adaptive immune responses. The accumulation of misfolded proteins in exposed children coincides with the anatomical distribution observed in the early stages of both Alzheimer's and Parkinson's diseases. We contend misfolding of hyperphosphorylated tau , alpha-synuclein, and beta-amyloid could represent a compensatory early protective response to the sustained systemic and brain inflammation. We favor the view that the chronic systemic and brain dysregulated inflammation and the diffuse vascular damage contribute to the establishment of neurodegenerative processes with childhood clinical manifestations. Friend turns Foe early; therefore, implementation of neuroprotective measures to ameliorate or stop the inflammatory and neurodegenerative processes is warranted in exposed children.

Early Alzheimer's and Parkinson's disease pathology in urban children: Friend versus Foe responses--it is time to face the evidence.Calderón-Garcidueñas L, Franco-Lira M, Mora-Tiscareño A, Medina-Cortina H, Torres-Jardón R, Kavanaugh M.Biomed Res Int. 2013;2013:161687.

Neuroinflammation, hyperphosphorylated tau, diffuse amyloid plaques, and down-regulation of the cellular prion protein in air pollution exposed children and young adults.Calderón-Garcidueñas L, Kavanaugh M, Block M, D'Angiulli A, Delgado-Chávez R, Torres-Jardón R, González-Maciel A, Reynoso-Robles R, Osnaya N, Villarreal-Calderon R, Guo R, Hua Z, Zhu H, Perry G, Diaz P.J Alzheimers Dis. 2012;28(1):93-107

Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults.Calderón-Garcidueñas L, Solt AC, Henríquez-Roldán C, Torres-Jardón R, Nuse B, Herritt L, Villarreal-Calderón R, Osnaya N, Stone I, García R, Brooks DM, González-Maciel A, Reynoso-Robles R, Delgado-Chávez R, Reed W.Toxicol Pathol. 2008 Feb;36(2):289-310.

Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution.Calderón-Garcidueñas L, Reed W, Maronpot RR, Henríquez-Roldán C, Delgado-Chavez R, Calderón-Garcidueñas A, Dragustinovis I, Franco-Lira M, Aragón-Flores M, Solt AC, Altenburg M, Torres-Jardón R, Swenberg JA.Toxicol Pathol. 2004 Nov-Dec;32(6):650-8.

Air pollution and brain damage.Calderón-Garcidueñas L, Azzarelli B, Acuna H, Garcia R, Gambling TM, Osnaya N, Monroy S, DEL Tizapantzi MR, Carson JL, Villarreal-Calderon A, Rewcastle B.Toxicol Pathol. 2002 May-Jun;30(3):373-89.

 

2. Children with no known risk factors for neurological or cognitive disorders residing in a polluted urban environment exhibited significant deficits in a combination of fluid and crystallized cognition tasks, white matter lesions and volumetric brain changes by MRI.

These very important findings explain many parents concerns regarding school performance and behavior in their otherwise healthy children. The effects of tiny particles on the developing brain translate in brain inflammation and structural alterations in key areas in their brain, i.e., the prefrontal cortex. We have shown brain responses to air pollution vary from child to child, while some produce certain types of proteins associated with neuroprotection, others have pro-inflammatory defensive responses that do not help in terms of cognition,nor in changes in brain volumes related to their age. Identification of biomarkers associating systemic inflammation to brain growth is critical for detecting children at higher risk for cognitive deficits and neurodegeneration, thereby warranting early implementation of neuroprotective measures.

Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs.

Calderón-Garcidueñas L, Mora-Tiscareño A, et al., Brain Cogn. 2008 Nov;68(2):117-27.

White matter hyperintensities, systemic inflammation, brain growth, and cognitive functions in children exposed to air pollution.

Calderón-Garcidueñas L1, Mora-Tiscareño A, Styner M, Gómez-Garza G, Zhu H, Torres-Jardón R, Carlos E, Solorio-López E, Medina-Cortina H, Kavanaugh M, D'Angiulli A. J Alzheimers Dis. 2012;31(1):183-91. doi: 10.3233/JAD-2012-120610.

3. Loss of smell i.e., the capacity to detect odors is an important early symptom of both Alzheimer and Parkinson’s diseases, present long before dementia or tremor.

Olfactory dysfunction influences nutrition, energy balance, enjoyment of food and their well-being under life threatening situations, including accidental gas poisonings. It is now apparent that the olfactory system undergoes neuropathological changes, neuroinflammation, DNA damage and accumulation of combustion-associated metals early in life in association with high levels of air pollution exposures.  It is also very important to know that people carrying the allele 4 of the Apolipoprotein E gene-the major genetic risk factor for Alzheimer’s disease-have early and more severe odor deficits if they live in polluted areas. Identification of vulnerable populations is important in order to protect them.

Urban air pollution: influences on olfactory function and pathology in exposed children and young adults.Calderón-Garcidueñas L, Franco-Lira M, Henríquez-Roldán C, Osnaya N, González-Maciel A, Reynoso-Robles R, Villarreal-Calderon R, Herritt L, Brooks D, Keefe S, Palacios-Moreno J, Villarreal-Calderon R, Torres-Jardón R, Medina-Cortina H, Delgado-Chávez R, Aiello-Mora M, Maronpot RR, Doty RL.Exp Toxicol Pathol. 2010 Jan;62(1):91-102.

4. The question to answer is: How can we protect children and young adults from the negative brain effects of air pollutants?

We are working on regular, available foods that will decrease inflammation, one of the key negative systemic and brain effects of air pollution. Cocoa and dark chocolate have been used in our laboratory to decrease brain inflammation with excellent results. In mice exposed to air pollution, dark chocolate (60% cacao) markedly decreased inflammation precisely in an area involved in Parkinson’s disease. In children, 30g of cocoa at breakfast time improved their memory and decreased a very powerful protein that reduces the lumen of blood vessels (vasoconstrictor).

Flavonol-rich dark cocoa significantly decreases plasma endothelin-1 and improves cognition in urban children.Calderón-Garcidueñas L1, Mora-Tiscareño A, Franco-Lira M, Cross JV, Engle R, Aragón-Flores M, Gómez-Garza G, Jewells V, Medina-Cortina H, Solorio E, Chao CK, Zhu H, Mukherjee PS, Ferreira-Azevedo L, Torres-Jardón R, D'Angiulli A. Front Pharmacol. 2013 Aug 22;4:104. doi: 10.3389/fphar.2013.00104.

Urban air pollution targets the dorsal vagal complex and dark chocolate offers neuroprotection. Villarreal-Calderon R, Torres-Jardón R, Palacios-Moreno J, Osnaya N, Pérez-Guillé B, Maronpot RR, Reed W, Zhu H, Calderón-Garcidueñas L. Int J Toxicol. 2010 Dec;29(6):604-15.

5. Obesity, insulin resistance, metabolic syndrome, cardiovascular disease and dementia.

Obesity is increasing in our populations, an ominous predictor of increases in metabolic syndrome, type 2 diabetes, cardiovascular disease and dementia. The problem is certainly a deep concern in socioeconomic disadvantage populations.

We need to look at the links between body mass index (BMI) and dementia because we can do something about the subject.  As physicians, we are very aware of the value of preventive medicine, starting in childhood and educating children and their parents about food and exercise is imperative.

 

We have a 50 year window of opportunity between urban children and young adults have the cognitive and metabolic detrimental effects we are describing in our laboratory, and they will present with mild cognitive impairment and dementia. APOE 4, the most prevalent genetic risk factor for AD has been understudied. Facing the current pediatric clinical and imaging evidence in highly exposed children is imperative if we are aiming our efforts to identify and mitigate environmental factors influencing Alzheimer’s disease. 


The University of Montana-Missoula
The Department of Biomedical & Pharmaceutical Sciences
32 Campus Drive, Skaggs 395
Missoula, MT 59812-1552
Phone 406.243.4767 Fax: 406.243.5228
Email: biomed@umontana.edu

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