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Josh.Lawrence

Profile

Name: Josh Lawrence

Title: Assistant Professor

Email: josh.lawrence@umontana.edu

Phone: 406-243-6486

Office: SB 391

Lab Phone: 406-243-6473

Lab: SB 385G

 

Background

After completing a BS in Biology at Allegheny College (1992) and post baccalaureate work at the University of Pennsylvania, Josh Lawrence received a Ph.D. in Neuroscience from the University of Wisconsin-Madison in 1999. Following graduate school, Josh was a postdoctoral fellow and staff scientist in Chris McBain’s laboratory at the National Institutes of Child Health and Human Development, National Institutes of Health. Josh started as an Assistant Professor at The University of Montana in August of 2008.

 

Research Statement

Neuronal rhythms in the brain temporally associate distinct aspects of sensory experience into a single collective percept. The neural basis of these rhythms, or oscillations, reflect the synchronized firing of neuronal ensembles driven by synaptic interactions between various subtypes of inhibitory interneurons and glutamatergic principal cells. Although these interneuron subtypes release the common inhibitory neurotransmitter GABA, there is growing recognition that these subclasses are themselves differentially regulated, performing fundamentally different physiological operations within neuronal microcircuits. As a consequence, each interneuron subclass makes a unique contribution to neuronal oscillations, and their contribution varies depending on the frequency of the oscillation and behavioral state. The emerging picture is that these interneuron subclasses play vital but different roles in the generation of behaviorally relevant neuronal rhythms.

Neuromodulatory systems (i.e. cholinergic, dopaminergic, noradrenergic, and serotonergic) transmit emotional and motivational information content to the sensory cortical areas, thereby contributing to cognitive processes such as attention, arousal, and learning. Changes in neuromodulatory control greatly impact the magnitude and frequency of oscillatory activity. Our lab is interested in how neuromodulation of distinct interneuron subclasses alters oscillatory activity and information processing.

Towards this end, our lab is developing transgenic and viral strategies for the systematic investigation of specific interneuron subtypes and developing new technologies that enable synaptic transmission between neuromodulatory neurons and interneuron targets to be examined at high resolution.

Finally, we are interested in the role of specific interneuron subclasses in the manifestation of disease states such as epilepsy and schizophrenia.

 

Publications

Lawrence J.J. Cholinergic control of GABA release: emerging parallels between neocortex and hippocampus.Trends Neurosci. 2008 Jul;31(7):317-27.

Lawrence J.J. Homosynaptic and heterosynaptic modes of endocannabinoid action at hippocampal CCK+ basket cell synapses (2007). J Physiol. Jan 1;578(Pt 1):3-4.

Lawrence J.J.*, Saraga F.*, Churchill J.F., Statland J.M., Travis K.E., McBain Skinner F.K., and McBain, C.J. (2006). Somatodendritic Kv7 channels control interspike interval in hippocampal interneurons. J Neurosci, Nov 22;26(47):12325-12338.
*These authors contributed equally to this work.

Lawrence J.J.*, Grinspan Z.M.*, Statland J.M., and McBain C.J. (2006). Muscarinic receptor activation tunes mouse stratum oriens interneurons to amplify spike reliability. J Physiol 571(Pt 3): 555-62.
*These authors contributed equally to this work.

Lawrence J.J., Statland J.M., Grinspan Z.M., and McBain C.J. (2006). Cell type- specific dependence of muscarinic signaling in mouse hippocampal stratum oriens interneurons. J Physiol 570(Pt 3): 595-610.

Lawrence J.J., Grinspan Z.M., and McBain C.J. (2003). Quantal transmission at mossy fiber targets in the CA3 region of the rat hippocampus. J Physiol 554(1):175-193.

Lawrence J.J., and McBain C.J. (2003). Interneuron Diversity series: Containing the detonation – feedforward inhibition in the CA3 hippocampus. Trends Neurosci 26(11): 631-640.

Lawrence J.J., Brenowitz S., and Trussell L.O. (2003). The mechanism of action of aniracetam at synaptic a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors: indirect and direct effects on desensitization. Mol Pharm 64(2): 269-278.

Walker H.C.*, Lawrence J.J.*, and McBain C.J. (2002). Activation of kinetically distinct synaptic conductances on inhibitory interneurons by electrotonically overlapping afferents. Neuron 35: 161-171.
*These authors contributed equally to this work.

Toth K., Suares G., Lawrence J.J., Philips-Tansey E., and McBain C.J. (2000). Differential mechanisms of transmission at three types of mossy fiber synapse, J Neurosci 20, 8279-89.

Lawrence J.J., and Trussell L.O. (2000). Long-term specification of AMPA receptor properties after synapse formation, J Neurosci 20, 4864-70.

Lynch D.R., Lawrence J.J., Lenz S., Anegawa N.J., Dichter M., and Pritchett D.B. (1995). Pharmacological characterization of heterodimeric NMDA receptors composed of NR 1a and 2B subunits: differences with receptors formed from NR 1a and 2A, J Neurochem 64, 1462-8.


The University of Montana-Missoula
The Department of Biomedical & Pharmaceutical Sciences
32 Campus Drive, Skaggs 395
Missoula, MT 59812-1552
Phone 406.243.4767 Fax: 406.243.5228
Email: biomed@umontana.edu

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